Perspectives

Axes de travail à l’avenir

  • Imagerie du développement du cerveau chez l’adolescent et l’enfant avec l’hypothèse que les périodes clés de la maturation cérébrale correspondent à des phases de transition et de vulnérabilité au risque de psychopathologie.
  • Une attention particulière sera portée à l’étude des interactions entre environnement et génétique au cours de ces périodes de transition et à leurs contributions à la vulnérabilité individuelle (Imagen).
  • Evaluation des stratégies thérapeutiques en psychiatrie. Recherche de descripteurs cérébraux de réponse ou de résistance aux thérapeutiques ou à l’addiction (http://clinicaltrials.gov/ct2/show/NCT00701532).
  • Prospects for the years to come

    Research will involve clinical departments in Paris Descartes / Paris Centre University (e.g. radiopaediatry in Necker hospital; adult, child and adolescent psychiatry departments), in Paris Sud University (e.g. addictology), and in Orsay hospital.

    1. Risk factors.The laboratory coordinates an international consortium Eranet-Neuron targeting adolescent neurocognitive processes in depression to promote intervention response : https://www.neuron-eranet.eu/_media/ADORe_summary.pdfAt-risk adolescents, young adults, and patients hospitalized for disorders tacking on emotional dysregulation or addiction will be investigated with respect to developmental databases.

      Since some mental disorders might be linked with measurable changes in brain structure development, investigations will focus on young subjects with autism spectrum disorder, or at risk for affective disorders, or for addictions (e.g. binge drinking). This objective will be pursued through joint research projects with teams experienced in genomics or epidemiology, in order to tackle relationships between neuroimages and genetic variables.

    2. Pharmaceutics & drug response. Objective brain descriptors of drugs effects will be searched, based on our experience of controlled therapeutic trials involving imaging patients with depression or schizophrenia.